CDKN2A-p16 Deletion and Activated KRASG12D Drive Barrett’s-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer LesionsSummary

Background & Aims: Barrett’s esophagus is the precursor of esophageal dysplasia and esophageal adenocarcinoma. CDKN2A-p16 deletions were reported in 34%–74% of patients with Barrett’s esophagus who progressed to dysplasia and esophageal adenocarcinoma, suggesting that p16 loss may drive neop...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Jing Sun, Jorge L. Sepulveda, Elena V. Komissarova, Caitlin Hills, Tyler D. Seckar, Narine M. LeFevre, Hayk Simonyan, Colin Young, Gloria Su, Armando Del Portillo, Timothy C. Wang, Antonia R. Sepulveda
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Barrett's metaplasia, CDKN2A-p16, KRAS, Dysplasia, Esophageal adenocarcinoma, Murine genetic models, 3D organoids, Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X24000146