Multiomics integrated analysis and experimental validation identify TLR4 and ALOX5 as oxidative stress-related biomarkers in intracranial aneurysms

Abstract Background Intracranial aneurysm (IA) is a severe cerebrovascular disease, and effective gene therapy and drug interventions for its treatment are still lacking. Oxidative stress (OS) is closely associated with the IA, but the key regulatory genes involved are still unclear. Through multiom...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Lvyin Luo, Xinlong Ma, Debin Kong, Yuxiang Dai, Tao Li, Han Yu, Jingzheng Liu, Maogui Li, Yangyang Xu, Guo Xiang, Zhimin Zhao, Weiying Zhong, Donghai Wang, Yunyan Wang
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Intracranial aneurysm Oxidative stress Bioinformatics analysis Single-cell sequencing Mouse IA model
Online Access:	https://doi.org/10.1186/s12974-024-03226-0