Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease:  plasma concentrations exceed target levels, with drug accumulation in the most severe patients

Background: TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with reference to efficacy (ET) and toxicology thresholds (TT). The relations...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Janet T. Scott, Raman Sharma, Luke W. Meredith, Jake Dunning, Catrin E. Moore, Foday Sahr, Steve Ward, Ian Goodfellow, Peter Horby
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396419308163