Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation. Donor T cell addback can accelerate immune reconstitution but the therapeutic window between graft-vs.-ho...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ping Zhang, Siok-Keen Tey
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-08-01
Subjects:	haploidentical transplant T cell immune reconstitution adoptive T cell therapy antigen-specific T cells safety switch gene modification
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01854/full