Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds...

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Bibliographic Details
Published in:eLife
Main Authors: Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Subjects:
Hedgehog signaling
oxysterol
smoothened
cysteine rich domain
Online Access:https://elifesciences.org/articles/01340

Internet

https://elifesciences.org/articles/01340

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