A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase

Summary: Increased de novo lipogenesis (DNL) is a major feature of nonalcoholic steatohepatitis (NASH). None of the drugs targeting the catalytic activity of acetyl-CoA carboxylase (ACC), the rate-limiting enzyme in the DNL process, have been approved by the FDA. Whether cytosolic ACC1 can be regula...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Yan Lin, Mingkun Yang, Li Huang, Fan Yang, Jiachen Fan, Yulong Qiang, Yuting Chang, Wenjie Zhou, Leilei Yan, Jie Xiong, Jie Ping, Shizhen Chen, Dong Men, Feng Li
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	CP: Metabolism CP: Microbiology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723014651