BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer

Abstract Background Approximately 3/4 of ovarian cancers are diagnosed in advanced stages, with the high‐grade epithelial ovarian carcinoma (EOC) accounting for 90% of the cases. EOC present high genomic instability and somatic loss‐of‐function variants in genes associated with homologous recombinat...

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Bibliographic Details

Published in:	Cancer Medicine
Main Authors:	Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina deArmas, Fábio Carvalho deBarros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dosSantos, Miguel Angelo Martins Moreira
Format:	Article
Language:	English
Published:	Wiley 2024-02-01
Subjects:	BRCA1 BRCA2 homologous recombination repair pathway ovarian cancer somatic mutation TP53
Online Access:	https://doi.org/10.1002/cam4.6729