RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice

Abstract Chronic antibody mediated rejection (AMR) is the major cause of solid organ graft rejection. Th17 contributes to AMR through the secretion of IL17A, IL21 and IL22. These cytokines promote neutrophilic infiltration, B cell proliferation and donor specific antibodies (DSAs) production. In the...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Ahmed Fouda, Mohamed Taoubane Maallah, Araz Kouyoumdjian, Sarita Negi, Steven Paraskevas, Jean Tchervenkov
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s42003-024-06144-2