Physiologically-based pharmacokinetic/pharmacodynamic modeling of meropenem in critically ill patients

Abstract This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic model (PBPK/PD) of meropenem for critically ill patients. A PBPK model of meropenem in healthy adults was established using PK-Sim software and subsequently extrapolated to critically ill patients based on a...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yujie Yang, Yirong Wang, Wei Zeng, Jinhua Zhou, Min Xu, Ying Lan, Lvye Liu, Jian Shen, Chuan Zhang, Qin He
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-08-01
Subjects:	Meropenem PBPK/PD Critically ill patients PK-Sim
Online Access:	https://doi.org/10.1038/s41598-024-64223-0