MDM2 inhibitor APG-115 synergizes with ABT-199 to induce cell apoptosis in chronic lymphocytic leukemia

Although clinical outcomes in chronic lymphocytic leukemia (CLL) have greatly improved with several approved small molecular inhibitors, acquired resistance does occur, leading to disease progression and eventual death. Thus, the effort to explore novel inhibitors and combination therapeutic regimen...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Ying Cui, Xiaoya Shao, Haiping Yang, Jingyi Xin, Yuanyuan Liu, Mingxiao Zhang, Chuanyue Sun, Ge Chen, Guomin Shen, Xueqiong Meng, Yixiang Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	chronic lymphocytic leukemia APG-115 apoptosis ABT-199 combination
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1441383/full