Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's...
| 出版年: | Frontiers in Neurology |
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| 主要な著者: | , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media S.A.
2018-05-01
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| 主題: | |
| オンライン･アクセス: | https://www.frontiersin.org/article/10.3389/fneur.2018.00394/full |
| _version_ | 1856997855743442944 |
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| author | Frederic Sampedro Frederic Sampedro Frederic Sampedro Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Saul Martínez-Horta Saul Martínez-Horta Saul Martínez-Horta Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky |
| author_facet | Frederic Sampedro Frederic Sampedro Frederic Sampedro Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Saul Martínez-Horta Saul Martínez-Horta Saul Martínez-Horta Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky |
| author_sort | Frederic Sampedro |
| collection | DOAJ |
| container_title | Frontiers in Neurology |
| description | The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators. Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline. |
| format | Article |
| id | doaj-art-d8a9ea971f924f5ea97d36efbfdadb41 |
| institution | Directory of Open Access Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-d8a9ea971f924f5ea97d36efbfdadb412025-08-19T19:51:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-05-01910.3389/fneur.2018.00394387084Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive DeclineFrederic Sampedro0Frederic Sampedro1Frederic Sampedro2Juan Marín-Lahoz3Juan Marín-Lahoz4Juan Marín-Lahoz5Saul Martínez-Horta6Saul Martínez-Horta7Saul Martínez-Horta8Javier Pagonabarraga9Javier Pagonabarraga10Javier Pagonabarraga11Jaime Kulisevsky12Jaime Kulisevsky13Jaime Kulisevsky14Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, SpainMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, SpainMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, SpainMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, SpainMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, SpainThe MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators. Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline.https://www.frontiersin.org/article/10.3389/fneur.2018.00394/fullMAPTT1-MRIcognitive declineParkinson's diseasegray matter volume |
| spellingShingle | Frederic Sampedro Frederic Sampedro Frederic Sampedro Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Saul Martínez-Horta Saul Martínez-Horta Saul Martínez-Horta Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline MAPT T1-MRI cognitive decline Parkinson's disease gray matter volume |
| title | Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline |
| title_full | Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline |
| title_fullStr | Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline |
| title_full_unstemmed | Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline |
| title_short | Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline |
| title_sort | early gray matter volume loss in mapt h1h1 de novo pd patients a possible association with cognitive decline |
| topic | MAPT T1-MRI cognitive decline Parkinson's disease gray matter volume |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00394/full |
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