Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent

Abstract Clostridioides difficile infection (CDI) is one of the five most urgent bacterial threats in the United States. Furthermore, hypervirulent CDI strains express a third toxin termed the C. difficile binary toxin (CDT), and its molecular mechanism for entering host cells is not fully elucidate...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Dinendra L. Abeyawardhane, Spiridon E. Sevdalis, Kaylin A. Adipietro, Raquel Godoy-Ruiz, Kristen M. Varney, Izza F. Nawaz, Alejandro X. Spittel, Daniel Hunter, Richard R. Rustandi, Vitalii I. Silin, Amedee des Georges, Mary E. Cook, Edwin Pozharski, David J. Weber
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Online Access:	https://doi.org/10.1038/s42003-025-08343-x