HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

Abstract Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and serves as a promising therapeutic target....

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Bibliographic Details

Published in:	Cancer Communications
Main Authors:	Ming Huang, Wen Dong, Ruihui Xie, Jilin Wu, Qiao Su, Wuguo Li, Kai Yao, Yuelong Chen, Qianghua Zhou, Qiang Zhang, Wenwen Li, Liang Cheng, Shengmeng Peng, Siting Chen, Jian Huang, Xu Chen, Tianxin Lin
Format:	Article
Language:	English
Published:	Wiley 2022-05-01
Subjects:	HSF1 PRMT5 KRIBB11 transcriptional program bladder cancer lymphatic metastasis
Online Access:	https://doi.org/10.1002/cac2.12284