IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.

The role of IL-27 in antiviral immunity is still incompletely understood, especially in the context of chronic viruses that induce a unique environment in their infected host. Cytomegalovirus (CMV) establishes a persistent, tissue localized infection followed by lifelong latency. CMV infects the maj...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Ellen J Wehrens, Kurt A Wong, Ankan Gupta, Ayesha Khan, Chris A Benedict, Elina I Zuniga
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0201249