Synthesis and Biological Evaluation of Novel 4-Morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine Derivatives Bearing Phenylpyridine/ Phenylpyrimidine-Carboxamides

Four series of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives 11a–j, 12a–j, 13a–g and 14a–g bearing phenylpyridine/phenylpyrimidine- carboxamide scaffolds were designed, synthesized and their IC50 values against three cancer cell lines (A549, PC-3 and MCF-7) were evaluated...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Molecules
المؤلفون الرئيسيون:	Huimin Liu, Wenhui Wang, Chengyu Sun, Caolin Wang, Wufu Zhu, Pengwu Zheng
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2016-10-01
الموضوعات:	thiopyrano[4,3-d]pyrimidine phenylpyridine/phenylpyrimidine carboxamides synthesis cytotoxicity activity PI3Kα kinase
الوصول للمادة أونلاين:	http://www.mdpi.com/1420-3049/21/11/1447