Mapping the genetic–transcriptional landscape of thyroid irAEs in sintilimab therapy: toward biomarker-guided immunotoxicity prediction

ObjectiveBy integrating whole-genome resequencing (WGR) with longitudinal transcriptomic profiling, this study aimed to unravel the genetic–transcriptional regulatory network underlying thyroid immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients treated with sintilim...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Wei Chen, Mingyu Zhang, Taifeng Li, Bing Shang, Haishuai Su, Yafei Shi, Yutao Liu, Feng Yu, Guohui Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	immune-related adverse events (irAEs) sintilimab eQTL analysis complement system longitudinal transcriptomics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1671594/full