Protocol to estimate the heritability of drug response with GxEMM and identify gene-drug interactions with TxEWAS

Summary: Identifying factors that affect treatment response is a central objective of clinical research. Here, we present a protocol to study the genetic architecture of response to commonly prescribed drugs using gene-context interaction techniques. We describe steps for estimating the heritability...

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Bibliographic Details

Published in:	STAR Protocols
Main Authors:	Michal Sadowski, Andy W. Dahl, Noah Zaitlen
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Bioinformatics Health Sciences Genetics Genomics Gene Expression Environmental sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666166725001868