PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

Abstract Class IIa histone deacetylases (Class IIa HDACs) play critical roles in regulating essential cellular metabolism and inflammatory pathways. However, dissecting the specific roles of each class IIa HDAC isoform is hindered by the pan‐inhibitory effect of current inhibitors and a lack of tool...

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書誌詳細

出版年:	Advanced Science
主要な著者:	Kailibinuer Kadier, Tian Niu, Baoli Ding, Boya Chen, Xuxin Qi, Danni Chen, Xirui Cheng, Yizheng Fang, Jiahao Zhou, Wenyi Zhao, Zeqi Liu, Yi Yuan, Zhan Zhou, Xiaowu Dong, Bo Yang, Qiaojun He, Ji Cao, Li Jiang, Cheng‐Liang Zhu
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2024-09-01
主題:	anti‐inflammatory drug development HDAC7 proinflammatory cytokines PROTAC TLR4 signaling
オンライン･アクセス:	https://doi.org/10.1002/advs.202309459