Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions

Abstract Active mobile elements in the human genome can create novel mobile element insertions (MEIs) in somatic tissues. Detection of somatic MEIs, particularly those with low mosaicism, remains a significant challenge due to sequencing artifacts and alignment errors. Existing methods lack sensitiv...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Miaomiao Tan, Zhinan Lin, Zhuofu Chen, Haonan Zhou, Junseok Park, Ziting He, Eunjung A. Lee, Zhipeng Gao, Xiaowei Zhu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41467-025-64237-w