Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

Summary: The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact in vivo is controversial. Here, we show that deletion of vpr is associated with...

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Bibliographic Details

Published in:	iScience
Main Authors:	Alexandre Laliberté, Caterina Prelli Bozzo, Christiane Stahl-Hennig, Victoria Hunszinger, Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Gregory K. Tharp, Dietmar Fuchs, Prachi Mehrotra Gupta, Guido Silvestri, Sydney A. Nelson, Laura Parodi, Luis Giavedoni, Steven E. Bosinger, Konstantin M.J. Sparrer, Frank Kirchhoff
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Immunology Immunity Immune response
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223024288