Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells

Abstract Orf virus (ORFV) is the causative agent of contagious ecthyma, which is an important zoonotic pathogen with a widespread distribution affecting sheep, goats and humans. Our previous research showed that autophagy can be induced in host cells by ORFV infection. However, the exact mechanism o...

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Bibliographic Details

Published in:	Veterinary Research
Main Authors:	Lijun Lv, Jiyu Guan, Ruixue Zhen, Pin Lv, Mengshi Xu, Xingyuan Liu, Shishi He, Ziyu Fang, Zi Li, Yungang Lan, Huijun Lu, Wenqi He, Feng Gao, Kui Zhao
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Subjects:	ORFV autophagy PI3K/AKT/mTOR ERK1/2/mTOR replication
Online Access:	https://doi.org/10.1186/s13567-023-01153-1