Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells

Abstract Orf virus (ORFV) is the causative agent of contagious ecthyma, which is an important zoonotic pathogen with a widespread distribution affecting sheep, goats and humans. Our previous research showed that autophagy can be induced in host cells by ORFV infection. However, the exact mechanism o...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Veterinary Research
المؤلفون الرئيسيون: Lijun Lv, Jiyu Guan, Ruixue Zhen, Pin Lv, Mengshi Xu, Xingyuan Liu, Shishi He, Ziyu Fang, Zi Li, Yungang Lan, Huijun Lu, Wenqi He, Feng Gao, Kui Zhao
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2023-03-01
الموضوعات:
ORFV
autophagy
PI3K/AKT/mTOR
ERK1/2/mTOR
replication
الوصول للمادة أونلاين:https://doi.org/10.1186/s13567-023-01153-1

الانترنت

https://doi.org/10.1186/s13567-023-01153-1

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