Epistasis and entrenchment of drug resistance in HIV-1 subtype B

The development of drug resistance in HIV is the result of primary mutations whose effects on viral fitness depend on the entire genetic background, a phenomenon called ‘epistasis’. Based on protein sequences derived from drug-experienced patients in the Stanford HIV database, we use a co-evolutiona...

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Bibliographic Details
Published in:eLife
Main Authors: Avik Biswas, Allan Haldane, Eddy Arnold, Ronald M Levy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Subjects:
epistasis
drug resistance
entrenchment
HIV
co-evolutionary model
Online Access:https://elifesciences.org/articles/50524

Internet

https://elifesciences.org/articles/50524

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