TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling

Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG). TGF-β can stimulate sulfated GAG production in nucleus pulposus cells; however, the underlying mechanisms are poorly understood....

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Bibliographic Details
Published in:Cellular Physiology and Biochemistry
Main Authors: Bo Hu, Changgui Shi, Ye Tian, Ying Zhang, Chen Xu, Huajiang Chen, Peng Cao, Wen Yuan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Subjects:
Nucleus pulposus
CHSY1
TGF-β
MAPK
Online Access:http://www.karger.com/Article/FullText/430396

Internet

http://www.karger.com/Article/FullText/430396

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