Prime-Editing of human ACTB in induced pluripotent stem cells to model human ACTB Loss-of-Function diseases and compensatory mechanisms

Beta-actin (ACTB) heterozygous loss-of-function mutations are associated with pleiotropic developmental disorders entailing intellectual disability and frequent organ malformations in affected individuals. We generated two CRISPR/Cas9 prime-edited human induced pluripotent stem cell (iPSC) lines, IU...

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Bibliographic Details

Published in:	Stem Cell Research
Main Authors:	Stephanie Binder, Haribaskar Ramachandran, Barbara Hildebrandt, Jochen Dobner, Andrea Rossi
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506124000023