NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial Cells

NADPH oxidases (NOXs) have been described as critical players in vascular remodeling, a mechanism modulated by matrix metalloproteinases. In this study, we describe for the first time the upregulation of MMP-10 through the activation of NOX5 in endothelial cells. In a chronic NOX5 overexpression mod...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Javier Marqués, Elena Ainzúa, Josune Orbe, María Martínez-Azcona, José Martínez-González, Guillermo Zalba
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Subjects:	oxidative stress NADPH oxidase 5 MMP-10 AP-1 cell migration endothelial cells
Online Access:	https://www.mdpi.com/2076-3921/13/10/1199