Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication

ABSTRACT DNA viruses at once elicit and commandeer host pathways, including DNA repair pathways, for virus replication. Despite encoding its own DNA polymerase and processivity factor, human cytomegalovirus (HCMV) recruits the cellular processivity factor, proliferating cell nuclear antigen (PCNA) a...

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Bibliographic Details
Published in:mBio
Main Authors: Pierce Longmire, Olivia Daigle, Sebastian Zeltzer, Matias Lee, Marek Svoboda, Marco Padilla-Rodriguez, Carly Bobak, Giovanni Bosco, Felicia Goodrum
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Subjects:
herpesvirus
cytomegalovirus
DNA Damage
DNA repair
PCNA
genome analysis
Online Access:https://journals.asm.org/doi/10.1128/mbio.00450-25

Internet

https://journals.asm.org/doi/10.1128/mbio.00450-25

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