Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS) spectra, 1H nuclear magnetic resonance (NMR)...

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發表在:	Molecules
Main Authors:	Mohamed F. Zayed, Saleh K. Ihmaid, Hany E. A. Ahmed, Khaled El-Adl, Ahmed M. Asiri, Abdelsattar M. Omar
格式:	Article
語言:	英语
出版:	MDPI AG 2017-01-01
主題:	design synthesis anticonvulsant quinazoline epilepsy neurotoxicity
在線閱讀:	http://www.mdpi.com/1420-3049/22/2/188