Carbonic Anhydrase IX-Targeted α-Radionuclide Therapy with 225Ac Inhibits Tumor Growth in a Renal Cell Carcinoma Model

In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-225 (<sup>225</sup>Ac) or the β<sup>-</sup>-emitter lutetium-177 (<sup>177</sup>...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Robin I. J. Merkx, Mark Rijpkema, Gerben M. Franssen, Annemarie Kip, Bart Smeets, Alfred Morgenstern, Frank Bruchertseifer, Eddie Yan, Michael P. Wheatcroft, Egbert Oosterwijk, Peter F. A. Mulders, Sandra Heskamp
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Subjects:
radioimmunotherapy
RCC
actinium-225
CAIX
G250
Online Access:https://www.mdpi.com/1424-8247/15/5/570

Internet

https://www.mdpi.com/1424-8247/15/5/570

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