SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification

Summary: Amino acid (aa) metabolism is closely correlated with the pathogenesis of psoriasis; however, details on aa transportation during this process are barely known. Here, we find that SLC38A5, a sodium-dependent neutral aa transporter that counter-transports protons, is markedly upregulated in...

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發表在:	Cell Reports
Main Authors:	Leqing Zhu, Xichun Xia, Guangqiang Li, Chuyun Zhu, Qingqing Li, Baocheng Wang, Nan-Xi Shi, Zhiwei Lei, Shuxian Yang, Zhanpeng Zhang, Haishan Li, Jingyi Tan, Zonghua Liu, Qiong Wen, Hui Zhong, Xue-Jia Lin, Guodong Sun, Xiucong Bao, Qian Wang, Liehua Deng, Lianghua Bin, Guangchao Cao, Zhinan Yin
格式:	Article
語言:	英语
出版:	Elsevier 2023-08-01
主題:	CP: Immunology
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S221112472300921X