G-CSF increases calprotectin expression, liver damage and neuroinflammation in a murine model of alcohol-induced ACLF

Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induced murine model of ACLF.Methods: ACLF was triggered by a singl...

Full description

Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Martí Ortega-Ribera, Yuan Zhuang, Veronika Brezani, Prashanth Thevkar Nagesh, Radhika S. Joshi, Mrigya Babuta, Yanbo Wang, Gyongyi Szabo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	acute-on-chronic liver failure inflammasome S100a8/S100a9 neutrophil BDL cerebellum
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1347395/full