Capturing the Heterogeneity of the PDAC Tumor Microenvironment: Novel Triple Co-Culture Spheroids for Drug Screening and Angiogenic Evaluation

Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges due to its desmoplastic reaction, which impedes therapeutic effectiveness, highlighting the need for advanced vitro models to better mimic the complex tumor environment. The current three-dimensional co-culture models...

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發表在:	Cells
Main Authors:	Ruben Verloy, Angela Privat-Maldonado, Jonas Van Audenaerde, Sophie Rovers, Hannah Zaryouh, Jorrit De Waele, Delphine Quatannens, Dieter Peeters, Geert Roeyen, Christophe Deben, Evelien Smits, Annemie Bogaerts
格式:	Article
語言:	英语
出版:	MDPI AG 2025-03-01
主題:	pancreatic ductal adenocarcinoma triple co-culture spheroids tumor microenvironment drug resistance heterogeneity angiogenesis
在線閱讀:	https://www.mdpi.com/2073-4409/14/6/450