Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cells, and as such constitute attractive targets for t...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tal Tilayov, Tal Hingaly, Yariv Greenshpan, Shira Cohen, Barak Akabayov, Roi Gazit, Niv Papo
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Subjects:	receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity
Online Access:	https://www.mdpi.com/1420-3049/25/20/4850