Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria

Abstract Background Parkinson’s disease (PD) is one of the neurodegeneration diseases characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the brain. Substantial evidence indicates that at the cellular level mitochondrial dysfunction is a key factor leadin...

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Bibliographic Details

Published in:	Translational Neurodegeneration
Main Authors:	Xiao-Yu Cheng, Sangita Biswas, Juan Li, Cheng-Jie Mao, Olga Chechneva, Jing Chen, Kai Li, Jiao Li, Jin-Ru Zhang, Chun-Feng Liu, Wen-Bin Deng
Format:	Article
Language:	English
Published:	BMC 2020-04-01
Subjects:	Parkinson’s disease iPSCs Dopaminergic neurons Rotenone Astrocytes Mitochondrial transfer
Online Access:	http://link.springer.com/article/10.1186/s40035-020-00190-6