High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.

Fibroblasts in the tumor microenvironment are a key determinant in cancer progression and may be a promising target for cancer therapy. Insulin-like growth factor binding protein 7 (IGFBP7) is known as a tumor suppressor in colorectal cancer (CRC). The present study investigated the inductive mechan...

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書誌詳細

出版年:	PLoS ONE
主要な著者:	Cui Rao, Shan-Li Lin, Wen-Jing Ruan, Huan Wen, Dan-Ju Wu, Hong Deng
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2014-01-01
オンライン･アクセス:	http://europepmc.org/articles/PMC3888407?pdf=render