Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis

There is a lack ofin vitromodels able to properly represent osteoarthritis (OA) synovial tissue (ST). We aimed to characterize OA ST and to investigate whether a mechanical or enzymatic digestion procedures influence synovial cell functional heterogeneity in vitro. Procedures using mechanical nondig...

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Bibliographic Details

Published in:	Biology
Main Authors:	Cristina Manferdini, Yasmin Saleh, Paolo Dolzani, Elena Gabusi, Diego Trucco, Giuseppe Filardo, Gina Lisignoli
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Subjects:	synovial cells synovial macrophages synovial fibroblasts isolation methods osteoarthritis
Online Access:	https://www.mdpi.com/2079-7737/9/12/459