Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation

Abstract Background The gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear. Given the key role of human dipeptidyl peptidase 4 (DPP4) in host metabolism, we investigate whether microbiota DPP4-like counterparts perfo...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Marta Olivares, Paula Hernández-Calderón, Sonia Cárdenas-Brito, Rebeca Liébana-García, Yolanda Sanz, Alfonso Benítez-Páez
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	DPP4 enzyme GLP-1 Gliptins Incretins Gut microbiome Obesity
Online Access:	https://doi.org/10.1186/s13059-024-03325-4