Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy

Abstract Nucleic acids from both self- and non-self-sources act as vital danger signals that trigger immune responses. Critical illnesses such as acute respiratory distress syndrome, sepsis, trauma and ischemia lead to the aberrant cytosolic accumulation and massive release of nucleic acids that are...

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Bibliographic Details

Published in:	Signal Transduction and Targeted Therapy
Main Authors:	Zhaorong Chen, Rayk Behrendt, Lennart Wild, Martin Schlee, Christian Bode
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-03-01
Online Access:	https://doi.org/10.1038/s41392-025-02174-2