MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

Perioperative hypersensitivity (POH) to the neuromuscular blocking drug (NMBD) rocuronium was previously thought to be IgE and mast cell (MC)-mediated. However, the recent seminal observation that rocuronium induces degranulation in murine peritoneal MCs (PMCs) via Mas-related G protein-coupled rece...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chalatip Chompunud Na Ayudhya, Aetas Amponnawarat, Saptarshi Roy, Carole A. Oskeritzian, Hydar Ali
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	anaphylaxis mast cells missense mutation MrgprB2 MRGPRX2 rocuronium
Online Access:	https://www.mdpi.com/2073-4409/10/1/156