Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

ABSTRACT Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important candidate for biological weapons. Currently...

Full description

Bibliographic Details
Published in:	Microbiology Spectrum
Main Authors:	Changqing Yu, Qi Wu, Jiuqing Xin, Qiujuan Yu, Zhixin Ma, Mengzhou Xue, Qingyuan Xu, Chunfu Zheng
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-06-01
Subjects:	smallpox variola virus vaccine design multi-epitopes vaccine
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.00465-24

Similar Items

Should Remaining Stockpiles of Smallpox Virus (Variola) Be Destroyed?
by: Raymond S. Weinstein
Published: (2011-04-01)

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
by: Reed F. Johnson, et al.
Published: (2021-08-01)

Smallpox eradication, laboratory visits, and a touch of tourism: travel notes of a Canadian scientist in Brazil Erradicando a varíola, visitando laboratórios e um pouco de turismo: notas de viagem de um cientista canadense ao Brasil
by: Steven Palmer, et al.
Published: (2010-01-01)

Evolution of means and principles of smallpox vaccination
by: S. V. Borisevich, et al.
Published: (2020-06-01)

Disease, religion and medicine: smallpox in nineteenth-century Benin Doenças, religião e medicina: a varíola no Benim, século XIX
by: Elisée Soumonni
Published: (2012-12-01)

Human monkeypox — After 40 years, an unintended consequence of smallpox eradication
by: Hussain Haider Shah, et al.
Published: (2023-01-01)

Employing an immunoinformatics approach revealed potent multi-epitope based subunit vaccine for lymphocytic choriomeningitis virus
by: Muhammad Waqas, et al.
Published: (2023-02-01)

Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea
by: Hwachul Shin, et al.
Published: (2024-09-01)

Preclinical Studies of the Specific Activity of the Live Culture Vaccine VACD6 against Smallpox and other Orthopoxvirus Infections
by: S. N. Shchelkunov, et al.
Published: (2023-01-01)

Knowledge, Actors and Strategies: Smallpox Vaccination in Mexico City, 1803-1872
by: Claudia Agostoni
Published: (2019-02-01)

Neurologic Complications of Smallpox Vaccination
by: J Gordon Millichap
Published: (2003-06-01)

Adventitious Viruses and Smallpox Vaccine
by: Claude Chastel
Published: (2005-11-01)

Modelling of optimal vaccination strategies in response to a bioterrorism associated smallpox outbreak
by: Valentina Costantino, et al.
Published: (2021-03-01)

Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach
by: Zxcy L. Nonog, et al.
Published: (2025-06-01)

An immunoinformatics approach to design a potential multi-epitope subunit vaccine against Bordetella pertussis
by: Sepideh Hozori, et al.
Published: (2023-01-01)

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections
by: Galina A. Shchelkunova, et al.
Published: (2022-12-01)

Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches
by: Rong Dong, et al.
Published: (2020-07-01)

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses
by: Diego Forni, et al.
Published: (2023-04-01)

The Rise of Mpox in a Post-Smallpox World
by: Jennifer H. McQuiston, et al.
Published: (2025-01-01)

An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis
by: Olugbenga S. Onile, et al.
Published: (2020-10-01)

Comprehensive immunoinformatics approach for developing a multi-epitope subunit vaccine against lumpy skin disease
by: Swati Rani, et al.
Published: (2025-12-01)

Immunoinformatics Approach to T-cell Epitopes in Human Immunodeficiency Virus
by: Deepa Chaturvedi, et al.
Published: (2013-12-01)

The Results of Re-certification of Reference Standard Sample Used for the Examination of Quality Smallpox Vaccines
by: A. V. Muhacheva, et al.
Published: (2016-12-01)

Legal measures on vaccination against smallpox in the Principality of Serbia in the 1830s-1840s
by: Kršljanin Nina
Published: (2021-01-01)

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity
by: Hao Liu, et al.
Published: (2024-12-01)

Dr. James Smith’s Dream of Eradicating Smallpox and the National Vaccine Institution
by: Hyon Ju LEE
Published: (2022-04-01)

Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics
by: Man Cui, et al.
Published: (2024-08-01)

When a Neglected Tropical Disease Goes Global: Knowledge, Attitudes and Practices of Italian Physicians towards Monkeypox, Preliminary Results
by: Matteo Riccò, et al.
Published: (2022-07-01)

Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study
by: Noriko Tomita, et al.
Published: (2023-03-01)

Immunoinformatics Approach to Designing a Subunit Vaccine Construct of Pseudomonas aeruginosa Outer Membrane Epitopes
by: Masoumeh Fathi1*
Published: (2024-09-01)

Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches
by: Vivitri Dewi Prasasty, et al.
Published: (2019-07-01)

Smallpox vaccination in a mouse model
by: S. N. Shchelkunov, et al.
Published: (2023-11-01)

Integrative immunoinformatics paradigm for predicting potential B-cell and T-cell epitopes as viable candidates for subunit vaccine design against COVID-19 virulence
by: Vyshnavie R. Sarma, et al.
Published: (2021-08-01)

A History of Smallpox Vaccination in Modern China: Vaccine Techniques, Instruments, and Localization
by: Jeongeun JO
Published: (2023-04-01)

Serological Immunity to Smallpox in New South Wales, Australia
by: Valentina Costantino, et al.
Published: (2020-05-01)

Correlations between Humoral Immunity, Vaccination Period and Demographic Characteristics of First Immunized Smallpox Vaccine Recipients
by: O. S. Ermilova, et al.
Published: (2020-03-01)

Low-Temperature Multiple Micro-Dispensing on Microneedles for Accurate Transcutaneous Smallpox Vaccination
by: Sang-Gu Yim, et al.
Published: (2022-04-01)

Immunoinformatics Approach for Epitope-Based Vaccine Design: Key Steps for Breast Cancer Vaccine
by: Aisyah Fitriannisa Prawiningrum, et al.
Published: (2022-11-01)

Frosted branch angiitis after smallpox vaccination
by: Kristen Collister, et al.
Published: (2022-09-01)

We should be prepared to smallpox re-emergence
by: S. N. Shchelkunov, et al.
Published: (2019-10-01)