Synthesis, DFT investigations, antioxidant, antibacterial activity and SAR-study of novel thiophene-2-carboxamide derivatives

Abstract Synthetic strategy for the synthesis of thiophene 2-carboxamide derivatives substituted with hydroxyl, methyl and amino groups at position-3 was proposed. The strategy includes the cyclization of the precursor ethyl 2-arylazo-3-mercapto-3-(phenylamino)acrylate derivatives, 2-acetyl-2-arylaz...

Full description

Bibliographic Details
Published in:BMC Chemistry
Main Authors: Heba M. Metwally, Norhan A. Khalaf, Ehab Abdel-Latif, Mohamed A. Ismail
Format: Article
Language:English
Published: BMC 2023-02-01
Subjects:
2-Chloroacetamide
Thiophene-2-carboxamide
Antioxidant
DFT calculations
Molecular docking
Online Access:https://doi.org/10.1186/s13065-023-00917-2

Internet

https://doi.org/10.1186/s13065-023-00917-2

Similar Items