Tumor matrix stiffness provides fertile soil for cancer stem cells

Abstract Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors and can promote proliferation, invasion, metastasis, drug resistance, and recurrence. Cancer stem ce...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Sadegh Safaei, Roya Sajed, Ahmad Shariftabrizi, Shima Dorafshan, Leili Saeednejad Zanjani, Masoumeh Dehghan Manshadi, Zahra Madjd, Roya Ghods
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	Extracellular matrix (ECM) Matrix Stiffness Mechanotransduction Cancer stem cells (CSC) Metastasis Chemoresistance
Online Access:	https://doi.org/10.1186/s12935-023-02992-w