Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells

Introduction: TNFα-inducible matrix metalloproteinases play a critical role in the process of airway remodeling in respiratory inflammatory disease including asthma. The cationic host defense peptide LL-37 is elevated in the lungs during airway inflammation. However, the impact of LL-37 on TNFα-driv...

Full description

Bibliographic Details

Published in:	Journal of Innate Immunity
Main Authors:	Anthony Altieri, Courtney Lynn Marshall, Padmanie Ramotar, Dylan Lloyd, Mahadevappa Hemshekhar, Victor Spicer, Anne M. van der Does, Neeloffer Mookherjee
Format:	Article
Language:	English
Published:	Karger Publishers 2024-03-01
Subjects:	cathelicidin ll-37 tnfα host defense peptides inflammation matrix metalloproteinases airway remodeling
Online Access:	https://beta.karger.com/Article/FullText/537775