Exploring the Structural Variability of Dynamic Biological Complexes by Single-Particle Cryo-Electron Microscopy

Biological macromolecules and assemblies precisely rearrange their atomic 3D structures to execute cellular functions. Understanding the mechanisms by which these molecular machines operate requires insight into the ensemble of structural states they occupy during the functional cycle. Single-partic...

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Bibliographic Details

Published in:	Micromachines
Main Authors:	Megan C. DiIorio, Arkadiusz W. Kulczyk
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	single-particle cryo-electron microscopy cryo-EM heterogeneity single-particle analysis SPA deep learning algorithms
Online Access:	https://www.mdpi.com/2072-666X/14/1/118