Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination

Abstract Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the ‘Warburg effect’ has been widely accepted as a key feature of rapidly proliferatin...

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Bibliographic Details

Published in:	Oncogenesis
Main Authors:	Henna Myllymäki, Lisa Kelly, Abigail M. Elliot, Roderick N. Carter, Jeanette Astorga Johansson, Kai Yee Chang, Justyna Cholewa-Waclaw, Nicholas M. Morton, Yi Feng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-01-01
Online Access:	https://doi.org/10.1038/s41389-024-00507-4