CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma

Natural Killer (NK) cells are known for their high intrinsic cytotoxic capacity, and the possibility to be applied as ‘off-the-shelf’ product makes them highly attractive for cell-based immunotherapies. In patients with multiple myeloma (MM), an elevated number of NK cells has been correlated with h...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann-Manrique, Ivana von Metzler, Toni Cathomen, Evelyn Ullrich
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Subjects:	Genome editing CRISPR-Cas NK cells inhibitory receptors immunotherapy NKG2A
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2022.2081415