Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after hepatitis B vaccination

The hepatitis B (HB) vaccine effectively prevents the incidence of hepatitis B virus (HBV) infection. However, vaccine failure occurs in 5–10% of the recipients. The precise mechanisms leading to responsiveness to the HB vaccine are poorly understood. High-throughput sequencing (HTS) may help clarif...

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Bibliographic Details

Published in:	Human Vaccines & Immunotherapeutics
Main Authors:	Akio Miyasaka, Yuichi Yoshida, Ting Wang, Yasuhiro Takikawa
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-11-01
Subjects:	hepatitis b vaccine t-cell receptor b-cell receptor repertoire diversity complementary determining region 3
Online Access:	http://dx.doi.org/10.1080/21645515.2019.1600987