BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators

Background Congenital heart defects are structural anomalies present at birth that can affect the function of the heart. Aneuploidy is a significant risk factor for congenital heart defects. Mosaic variegated aneuploidy syndrome, caused by mutations in Bub1b (encoding BubR1, a mitotic checkpoint pro...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Renju Pun, Aradhana Thapa, Sylar R. Takafuji, Rexton M. Suzuki, Gabrielle F. Kay, Toni D. Howard, Michael H. Kim, Brian J. North
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Subjects:	BubR1 cardiac development congenital heart defects MVA syndrome single‐cell RNA sequencing
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.124.038286