DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

α-Synuclein misfolding and aggregation play an important role in the pathogenesis of Parkinson’s disease (PD). Loss of function and mutation of the PARK7/DJ-1 gene cause early-onset familial PD. DJ-1 can inhibit α-synuclein aggregation, and may function at an early step in the aggregation process. S...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Chuan-Ying Xu, Wen-Yan Kang, Yi-Meng Chen, Tian-Fang Jiang, Jia Zhang, Li-Na Zhang, Jian-Qing Ding, Jun Liu, Sheng-Di Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-09-01
Subjects:	Parkinson’s disease α-synuclein DJ-1 chaperone-mediated autophagy LAMP2A
Online Access:	http://journal.frontiersin.org/article/10.3389/fnagi.2017.00308/full