Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters

The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug absorption by inhibiting intestinal drug transport...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara, Khondoker Alam, Andre Raw, Bhagwant Rege, Liang Zhao, Dongmei Lu, Lei Zhang, Lawrence X. Yu, Robert A. Lionberger, Kathleen M. Giacomini, Deanna L. Kroetz, Sook Wah Yee
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	nitrosamine antioxidants intestinal transporters OATP2B1 BCRP P-gp
Online Access:	https://www.mdpi.com/1999-4923/16/5/647