Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

Abstract As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers. In order to explore novel PARP-1 inhibitors, a series of 22 novel erythrina derivatives were reported...

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Bibliographic Details

Published in:	BMC Chemistry
Main Authors:	Ling Yu, Jian-hui Li, Ju Zhu, You-de Wang, Zhi-wei Yan, Li-ying Zhang, Shuai Li
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	PARP-1 inhibitor Antitumor Apoptosis Drug discovery
Online Access:	https://doi.org/10.1186/s13065-023-01060-8